Chapter 5 MIRN 211 ( microRNA 211 )

Chapter 3 MIRN 211 ( microRNA 211 )

MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA

Recent studies have shown that microRNAs play a pivotal role in the pathogenesis of cancer. In our current study, the expression levels of microRNA-211 (miR-211) were measured in human non-small-cell lung cancer (NSCLC) tissues and cell lines. We found that miR-211 expression levels were increased in NSCLC tissues and cell lines and that the overexpression of miR-211 promotes cell proliferation...

MicroRNA-211 Expression Promotes Colorectal Cancer Cell Growth In Vitro and In Vivo by Targeting Tumor Suppressor CHD5

BACKGROUND Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a newly identified tumor suppressor that is frequently downregulated in a variety of human cancers. Our previous work revealed that the low expression of CHD5 in colorectal cancer is correlated with CHD5 promoter CpG island hypermethylation. In this study, we investigated the effect of microRNA-211 (miR-211)-regulated CHD5 express...

Feed-Forward Microprocessing and Splicing Activities at a MicroRNA–Containing Intron

The majority of mammalian microRNA (miRNA) genes reside within introns of protein-encoding and non-coding genes, yet the mechanisms coordinating primary transcript processing into both mature miRNA and spliced mRNA are poorly understood. Analysis of melanoma invasion suppressor miR-211 expressed from intron 6 of melastatin revealed that microprocessing of miR-211 promotes splicing of the exon 6...

MicroRNA-211 inhibits tumor growth and invasion through directly targeting RUNX2 in osteosarcoma

Osteosarcoma is the most common primary neoplasm of the bone and mainly occurs in adolescents and young adults. Despite great progress in current treatments, approximately one-third of patients with OS will not survive for more than five years, and fewer than 50% will live more than ten years. Aberrantly expressed microRNAs contribute to the carcinogenesis and progression of human cancers, incl...